abstract：:Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV-) groups have not been studied with similar methods in the pr...

journal_title：Journal of neurovirology

authors： Heaton RK,Franklin DR,Ellis RJ,McCutchan JA,Letendre SL,Leblanc S,Corkran SH,Duarte NA,Clifford DB,Woods SP,Collier AC,Marra CM,Morgello S,Mindt MR,Taylor MJ,Marcotte TD,Atkinson JH,Wolfson T,Gelman BB,McArthur JC,

更新日期：2011-02-01 00:00:00

abstract：:Chemokines influence HIV neuropathogenesis by affecting the HIV life cycle, trafficking of macrophages into the nervous system, glial activation, and neuronal signaling and repair processes; however, knowledge of their relationship to in vivo measures of cerebral injury is limited. The primary objective of this study ...

journal_title：Journal of neurovirology

authors： Letendre SL,Zheng JC,Kaul M,Yiannoutsos CT,Ellis RJ,Taylor MJ,Marquie-Beck J,Navia B,HIV Neuroimaging Consortium.

更新日期：2011-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dement...

journal_title：Journal of neurovirology

authors： Gray LR,Gabuzda D,Cowley D,Ellett A,Chiavaroli L,Wesselingh SL,Churchill MJ,Gorry PR

更新日期：2011-02-01 00:00:00

abstract：:Varicella-zoster virus (VZV) is a ubiquitous human herpes virus typically acquired in childhood when it causes varicella (chickenpox), following which the virus establishes a latent infection in trigeminal and dorsal root ganglia that lasts for the life of the individual. VZV subsequently reactivates, spontaneously or...

journal_title：Journal of neurovirology

authors： Kennedy PG,Cohrs RJ

更新日期：2010-11-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) and viral proteins affect neuronal survival and neuron-glial cell interactions, which culminate in neurological disorders. HIV-1 infects regions of neurogenesis in human adult and pediatric brain. However, little is known about the effect of HIV-1 or viral proteins on the pr...

journal_title：Journal of neurovirology

authors： Mishra M,Taneja M,Malik S,Khalique H,Seth P

更新日期：2010-10-01 00:00:00

abstract：:Because interruptions of antiretroviral treatment may entail clinical risks for human immunodeficiency virus (HIV)-infected individuals, we investigated their impact on neurocognitive functioning. Cross-sectional study was carried out, comparing HIV-infected persons who had interrupted antiretroviral therapy in the pa...

journal_title：Journal of neurovirology

authors： Muñoz-Moreno JA,Fumaz CR,Prats A,Ferrer MJ,Negredo E,Pérez-Alvarez N,Moltó J,Gómez G,Garolera M,Clotet B

更新日期：2010-05-01 00:00:00

abstract：:The interplay between pathology and human immunodeficiency virus (HIV) expansion in brain tissues has not been thoroughly assessed in the highly active antiretroviral therapy (HAART) era. HIV-associated dementia (HAD) is marked by progressive brain infection due to recruitment and migration of macrophages in brain tis...

journal_title：Journal of neurovirology

authors： Lamers SL,Salemi M,Galligan DC,Morris A,Gray R,Fogel G,Zhao L,McGrath MS

更新日期：2010-05-01 00:00:00

abstract：:We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and b...

journal_title：Journal of neurovirology

authors： Arslan F,Tabak F,Avşar E,Midilli K,Mert A,Ozaras R,Soysal T,Ozturk R,Ferhanoglu B

更新日期：2010-03-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is an important cause of neurologic disease in the context of advanced human immunodeficiency virus (HIV) infection and is recognized as a cause of immune reconstitution inflammatory syndrome (IRIS) after initiation of highly active antiretroviral therapy (HAART). Central nervous system...

journal_title：Journal of neurovirology

authors： Anderson AM,Fountain JA,Green SB,Bloom SA,Palmore MP

更新日期：2010-03-01 00:00:00

abstract：:Excessive glutamate neurotransmission has been implicated in neuronal injury in many disorders of the central nervous system (CNS), including human immunodeficiency virus (HIV)-associated dementia. Gp120IIIB is a strain of a HIV glycoprotein with specificity for the CXCR4 receptor that induces neuronal apoptosis in in...

journal_title：Journal of neurovirology

authors： Thomas AG,Bodner A,Ghadge G,Roos RP,Slusher BS

更新日期：2009-09-01 00:00:00

abstract：:Glycogen synthase kinase-3beta (GSK3beta) role in human immunodeficiency virus(HIV)-associated neurodegeneration has been evidenced by previous investigations. In this study, we investigated the specificity of two GSK3beta-specific inhibitors, AR-A014418 (A) and B6B30 (B) to prevent direct neurotoxicity in primary hum...

journal_title：Journal of neurovirology

authors： Nguyen TB,Lucero GR,Chana G,Hult BJ,Tatro ET,Masliah E,Grant I,Achim CL,Everall IP,HIV Neurobehavioral Research Group.

更新日期：2009-09-01 00:00:00

abstract：:Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. We hypothesized that natalizumab may also lead to reactivation of BK, a related human polyomavirus capable of causing morbidity in immunosuppressed groups. Patients with relapsing remi...

journal_title：Journal of neurovirology

authors： Lonergan RM,Carr MJ,De Gascun CF,Costelloe LF,Waters A,Coughlan S,Duggan M,Doyle K,Jordan S,Hutchinson MW,Hall WW,Tubridy NJ

更新日期：2009-09-01 00:00:00

abstract：:The objective of this study was to assess lithium safety and tolerability and to explore its impact on cognition, function, and neuroimaging biomarkers in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. Fifteen cognitively impaired HIV-infected subjects were enrolled in this 10-week ope...

journal_title：Journal of neurovirology

authors： Schifitto G,Zhong J,Gill D,Peterson DR,Gaugh MD,Zhu T,Tivarus M,Cruttenden K,Maggirwar SB,Gendelman HE,Dewhurst S,Gelbard HA

更新日期：2009-04-01 00:00:00

abstract：:We report varicella-zoster virus (VZV) meningitis in a healthy adult woman with no antecedent rash and with hypoglycorrhachia. Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody. ...

journal_title：Journal of neurovirology

authors： Habib AA,Gilden D,Schmid DS,Safdieh JE

更新日期：2009-04-01 00:00:00

abstract：:Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infe...

journal_title：Journal of neurovirology

authors： Tsunoda I,Tanaka T,Taniguchi M,Fujinami RS

更新日期：2009-01-01 00:00:00

abstract：:This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot b...

journal_title：Journal of neurovirology

authors： Dolei A,Perron H

更新日期：2009-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) associated central nervous system (CNS) infection is a rare disease. We report an atypical manifestation of EBV encephalitis initially presenting with a tumor-like lesion of the optic tract in an immunocompromised patient 8 years after a combined kidney and pancreas transplantation had been pe...

journal_title：Journal of neurovirology

authors： Khalil M,Enzinger C,Wallner-Blazek M,Scarpatetti M,Barth A,Horn S,Reiter G

更新日期：2008-11-01 00:00:00

abstract：:Although no longer considered therapeutically beneficial, antiretroviral treatment interruptions (TIs) still occur frequently among patients with human immunodeficiency virus (HIV) infection for a variety of reasons. TIs typically result in viral rebound and worsening immunosuppression, which in turn are risk factors ...

journal_title：Journal of neurovirology

authors： Childers ME,Woods SP,Letendre S,McCutchan JA,Rosario D,Grant I,Mindt MR,Ellis RJ,San Diego HIV Neurobehavioral Research Center Group.

更新日期：2008-11-01 00:00:00

abstract：:Human Immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), also manifests neurological complications. HIV-associated dementia (HAD) is the most severe form of HIV-induced neurocognitive disorders. HIV encephalitis (HIVE), the pathological correlate of HAD, is characterized by ...

journal_title：Journal of neurovirology

authors： Williams R,Bokhari S,Silverstein P,Pinson D,Kumar A,Buch S

更新日期：2008-08-01 00:00:00

abstract：:Activated murine cytotoxic T cells express the NKG2D natural cytotoxicity receptor. This receptor recognizes major histocompatibility complex (MHC) class I-like molecules expressed on the surface of infected cells and serves to augment T cell-mediated cytotoxicity. The role of NKG2D-mediated augmentation in the cleara...

journal_title：Journal of neurovirology

authors： Deb C,Howe CL

更新日期：2008-05-01 00:00:00

abstract：:The causes of Alzheimer's disease (AD) and of the characteristic pathological features - amyloid plaques and neurofibrillary tangles - of AD brain are unknown, despite the enormous resources provided over the years for their investigation. Indeed, the only generally accepted risk factors are age, Down syndrome, carria...

journal_title：Journal of neurovirology

authors： Itzhaki RF,Cosby SL,Wozniak MA

更新日期：2008-01-01 00:00:00

abstract：:Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States, can both impair the functions of macrophages and CD4(+) lymphocytes and also activate human immunodeficiency vi...

journal_title：Journal of neurovirology

authors： Dhillon NK,Williams R,Peng F,Tsai YJ,Dhillon S,Nicolay B,Gadgil M,Kumar A,Buch SJ

更新日期：2007-12-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-associated neuropathogenesis occurs in a large minority of infected people. Presently, there are neither viral nor cellular markers that predict the development of brain disease during HIV-1 infection. This study was conducted to determine whether there exist systematic diff...

journal_title：Journal of neurovirology

authors： Kazmierczak K,Potash MJ

更新日期：2007-10-01 00:00:00

abstract：:A postmarketing surveillance study was undertaken to investigate the safety and efficacy of interferon-alpha for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) under routine treatment conditions. A total of 273 cases from 91 medical institutions were registered into the survey. So far, 167...

journal_title：Journal of neurovirology

authors： Arimura K,Nakagawa M,Izumo S,Usuku K,Itoyama Y,Kira J,Osame M

更新日期：2007-08-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) dementia remains as an important cause of neurological morbidity among HIV-seropositive (HIV+) individuals. Differences in the neuropsychological profiles between older and younger HIV+ individuals have not been examined extensively. The objective of this study was to examine the neu...

journal_title：Journal of neurovirology

authors： Sacktor N,Skolasky R,Selnes OA,Watters M,Poff P,Shiramizu B,Shikuma C,Valcour V

更新日期：2007-06-01 00:00:00

abstract：:Viral oncolytic therapy for malignant brain tumors involves local intratumoral delivery of a genetically engineered virus with tumor cell-specific lytic activity. Promising preliminary results have been achieved in preclinical models with G207, a replication-competent herpes simplex virus type 1 constructed with multi...

journal_title：Journal of neurovirology

authors： Radbill AE,Reddy AT,Markert JM,Wyss JM,Pike MM,Akella NS,Bharara N,Gillespie GY

更新日期：2007-04-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) has been implicated in neurological complications in developed countries. Developing countries have different viral clades and potentially different genetic and social risks for these complications. Baseline neurological performance measures associated with HIV infection have rarely ...

journal_title：Journal of neurovirology

authors： Clifford DB,Mitike MT,Mekonnen Y,Zhang J,Zenebe G,Melaku Z,Zewde A,Gessesse N,Wolday D,Messele T,Teshome M,Evans S

更新日期：2007-01-01 00:00:00

abstract：:After uniocular anterior chamber (AC) inoculation of herpes simplex virus type 1 (HSV-1), virus and TNF alpha (TNF-alpha) are detected in the suprachiasmatic nuclei (SCN). The goal of this study was to investigate the role of TNF-alpha and macrophages in the brain of HSV-1-infected BALB/c mice. Mice were treated with ...

journal_title：Journal of neurovirology

authors： Fields M,Zheng M,Zhang M,Atherton SS

更新日期：2006-12-01 00:00:00

abstract：:Maintaining the viral genome intact following infection and prior to replication is critical to the virus life cycle. Here we report an analysis of the stability of herpes simplex virus type 1 (HSV-1) genomes, relative to host chromosomal DNA, in infected cells as a function of viral induced apoptosis. The results sho...

journal_title：Journal of neurovirology

authors： Su YH,Zhang X,Aiamkitsumrit B,Tang Q,Maul G,Fraser NW,Block TM

更新日期：2006-10-01 00:00:00

abstract：:Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection. The appearance of viral RNA is particularly prominent in the cerebrospinal fluid (CSF), suggesting an efficient route of virus transfer across the blood-CSF...

journal_title：Journal of neurovirology

authors： Liu P,Hudson LC,Tompkins MB,Vahlenkamp TW,Colby B,Rundle C,Meeker RB

更新日期：2006-08-01 00:00:00

abstract：:Although animal parvoviruses have long been recognized as causes of brain pathology in multiple animal models, especially during early development, human parvoviruses are rarely thought of as neurotropic or causes of neuropathology in humans. However, several recent case reports have suggested possible associations of...

journal_title：Journal of neurovirology

authors： Hobbs JA

更新日期：2006-06-01 00:00:00

abstract：:Gliomas are the most frequent primary brain tumors in humans. Many studies have been carried out on their etiology; however, the only confirmed risk factors are hereditary predisposing conditions and high dose of ionizing radiation. Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported t...

journal_title：Journal of neurovirology

authors： Poltermann S,Schlehofer B,Steindorf K,Schnitzler P,Geletneky K,Schlehofer JR

更新日期：2006-04-01 00:00:00

abstract：:A significant number of human immunodeficiency virus type 1 (HIV-1)-infected patients are alcoholics. Either alcohol or HIV alone induces morphological and functional damage to the nervous system. HIV-1 Tat is a potent transcriptional activator of the viral promoter, with the ability to modulate a number of cellular r...

journal_title：Journal of neurovirology

authors： Brailoiu E,Brailoiu GC,Mameli G,Dolei A,Sawaya BE,Dun NJ

更新日期：2006-02-01 00:00:00

abstract：:The latency-related (LR) RNA of bovine herpes virus 1 (BHV-1) is abundantly expressed in sensory neurons of latently infected cattle. Wild-type expression of LR gene products is required for the latency-reactivation cycle. LR gene products inhibit apoptosis, bICP0 expression, and mammalian cell growth. The cell growth...

journal_title：Journal of neurovirology

authors： Geiser V,Jones C

更新日期：2005-12-01 00:00:00

abstract：:Nipah virus is a recently emergent paramyxovirus that is capable of causing severe disease in both humans and animals. The first outbreak of Nipah virus occurred in Malaysia and Singapore in 1999 and, more recently, outbreaks were detected in Bangladesh. In humans, Nipah virus causes febrile encephalitis with respirat...

journal_title：Journal of neurovirology

authors： Bellini WJ,Harcourt BH,Bowden N,Rota PA

更新日期：2005-10-01 00:00:00

abstract：:In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigemi...

journal_title：Journal of neurovirology

authors： Kent JR,Fraser NW

更新日期：2005-08-01 00:00:00

abstract：:To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the...

journal_title：Journal of neurovirology

authors： Takemoto M,Kira R,Kusuhara K,Torisu H,Sakai Y,Hara T

更新日期：2005-07-01 00:00:00

abstract：:Over the past decade there has been a revolution in the understanding and care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-associated disease. Much of this progress stems from a broader recognition of the importance of differences in viral types, including receptor preference(s), repl...

journal_title：Journal of neurovirology

authors： van Marle G,Power C

更新日期：2005-04-01 00:00:00

abstract：:In the highly active antiretroviral therapy (HAART) era, the role of the inflammatory response in acquired immunodeficiency syndrome (AIDS)-related progressive multifocal leukoencephalopathy (PML) remains controversial. In this study, JC virus DNA load and levels of cytokines were determined in cerebrospinal fluid (CS...

journal_title：Journal of neurovirology

authors： Marzocchetti A,Cingolani A,Giambenedetto SD,Ammassari A,Giancola ML,Cauda R,Antinori A,Luca AD

更新日期：2005-04-01 00:00:00

abstract：:JC virus (JCV) is a human polyomavirus that exists in at least eight different genotypes as a result of coevolution with different human populations all over the world. Well adapted to its host, it usually persists in the kidneys and possibly the brain. If the host becomes immunodeficient, JCV can cause the fatal demy...

journal_title：Journal of neurovirology

authors： Eberwein P,Hansen LL,Agostini HT

更新日期：2005-02-01 00:00:00